4-Pyridinecarbonitrile, 2-(trifluoromethyl)-

4-Pyridinecarbonitrile, 2-(trifluoromethyl)- - Names and Identifiers

Name	2-(Trifluoromethyl) isonicotinonitrile
Synonyms	2-Trifluoromethyl-isonicotinonitrile 2-(Trifluoromethyl)isonicotinonitrile 2-(Trifluoromethyl) isonicotinonitrile 2-(trifluoroMethyl)pyridine-4-carbonitrile 2-(trifluoromethyl)pyridine-4-carbonitrile 4-pyridinecarbonitrile, 2-(trifluoromethyl)- 4-Pyridinecarbonitrile, 2-(trifluoromethyl)- 2-(Trifluoromethyl)pyridine-4-carbonitrile, 4-Cyano-2-(trifluoromethyl)pyridine
CAS	916210-02-1
InChI	InChI=1S/C7H3F3N2/c8-7(9,10)6-3-5(4-11)1-2-12-6/h1-3H

4-Pyridinecarbonitrile, 2-(trifluoromethyl)- - Physico-chemical Properties

Molecular Formula	C7H3F3N2
Molar Mass	172.11
Density	1.37±0.1 g/cm3(Predicted)
Boling Point	186.4±35.0 °C(Predicted)
pKa	-2.80±0.20(Predicted)
Storage Condition	2-8°C

4-Pyridinecarbonitrile, 2-(trifluoromethyl)- - Introduction

2-(Trifluoromethyl) isonicotinonitrile is an organic compound with the chemical formula C7H2F3N. The following is a description of its nature, use, preparation and safety information:

Nature:
2-(Trifluoromethyl) isonicotinonitrile is a solid with white to light yellow crystals. It has a melting point of about 107°C -109°C. It is soluble in organic solvents, such as ether and chloroform, and has a low solubility in water.

Use:
2-(Trifluoromethyl) isonicotinonitrile is often used as an important intermediate in organic synthesis. It can be used to synthesize various organic compounds, such as drugs, pesticides and ligands. Due to the introduction of the trifluoromethyl group, the properties and activities of the compounds can be changed, which is widely used in the fields of medicine, pesticide and material science.

Method: There are two main methods for preparing
2-(Trifluoromethyl) isonicotinonitrile. One is obtained by oxidizing nicotinonitrile, first reacting nicotinonitrile with phosphorus oxychloride, and then adding trifluoromethyl sodium iodide to react to obtain the target product. The other is prepared by the reaction of fluorinated sodium trinitride and trifluoronitrile.

Safety Information:
2-(Trifluoromethyl) isonicotinonitrile need to pay attention to protective measures during operation. It may cause irritation and damage to the skin, eyes and respiratory tract. Therefore, use should wear protective gloves, goggles and protective masks. During storage and transportation, it should be ensured that there is no contact with oxidants, strong acids and strong bases. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical attention.

Last Update：2024-04-09 20:48:19